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erk inhibitor sch772984  (MedChemExpress)


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    Structured Review

    MedChemExpress erk inhibitor sch772984
    Erk Inhibitor Sch772984, supplied by MedChemExpress, used in various techniques. Bioz Stars score: 98/100, based on 289 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/product/erk+inhibitor+sch772984/SCH772984/pm42010022-202-12-15
    Average 98 stars, based on 289 article reviews
    erk inhibitor sch772984 - by Bioz Stars, 2026-09
    98/100 stars

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    Related Articles

    Negative Control:

    Article Title: Plantaricin BM-1 enhances anti-colorectal cancer effects by inhibiting CD8+ cytotoxic T cell apoptosis via the ERK/AP1/Bim signaling pathway
    Article Snippet: Antibody information: CD8 (Servicebio, Wuhan, China). .. To assess the effects of Plantaricin BM-1 on ERK and Bim, we treated complete culture medium (negative control), different concentrations of Plantaricin BM-1 (5120 AU/ml and 10240 AU/ml), along with the ERK inhibitor SCH772984 (MCE, Shanghai, China, 0.5 μM, positive control) to treat mouse spleen CD8 + T cells, followed by incubation for 1 hour. .. Cells were then lysed and proteins were extracted using a protein extraction kit (GenePool, Beijing, China).

    Positive Control:

    Article Title: Plantaricin BM-1 enhances anti-colorectal cancer effects by inhibiting CD8+ cytotoxic T cell apoptosis via the ERK/AP1/Bim signaling pathway
    Article Snippet: Antibody information: CD8 (Servicebio, Wuhan, China). .. To assess the effects of Plantaricin BM-1 on ERK and Bim, we treated complete culture medium (negative control), different concentrations of Plantaricin BM-1 (5120 AU/ml and 10240 AU/ml), along with the ERK inhibitor SCH772984 (MCE, Shanghai, China, 0.5 μM, positive control) to treat mouse spleen CD8 + T cells, followed by incubation for 1 hour. .. Cells were then lysed and proteins were extracted using a protein extraction kit (GenePool, Beijing, China).

    Incubation:

    Article Title: Plantaricin BM-1 enhances anti-colorectal cancer effects by inhibiting CD8+ cytotoxic T cell apoptosis via the ERK/AP1/Bim signaling pathway
    Article Snippet: Antibody information: CD8 (Servicebio, Wuhan, China). .. To assess the effects of Plantaricin BM-1 on ERK and Bim, we treated complete culture medium (negative control), different concentrations of Plantaricin BM-1 (5120 AU/ml and 10240 AU/ml), along with the ERK inhibitor SCH772984 (MCE, Shanghai, China, 0.5 μM, positive control) to treat mouse spleen CD8 + T cells, followed by incubation for 1 hour. .. Cells were then lysed and proteins were extracted using a protein extraction kit (GenePool, Beijing, China).

    Activity Assay:

    Article Title: A naturally synonymous mutation modulates an ERK-centered regulatory network to mediate thermotolerance divergence in Crassostrea oysters.
    Article Snippet: .. After two-week acclimation in aerated seawater (18±2°C), dose-response experiments were conducted with ERK inhibitor SCH772984 (MCE, USA; CatHY50846), which effectively blocks both ERK activity and phosphorylation108–110. ..

    Concentration Assay:

    Article Title: RLIG1 promotes triple-negative breast cancer proliferation by activating mTORC1 signal pathway by interacting with ERK.
    Article Snippet: Background: The prognosis of triple-negative breast cancer (TNBC) is notably unfavorable, necessitating the development of novel treatments to enhance therapeutic outcomes.. The underlying mechanisms contributing to the pathogenesis of TNBC remain incompletely understood.. RNA 5′-phosphate and 3’-OH ligase 1 (RLIG1) was found to be the first RNA ligase in humans and may be related to cancer development, but no reports have been reported.

    Inhibition:

    Article Title: RLIG1 promotes triple-negative breast cancer proliferation by activating mTORC1 signal pathway by interacting with ERK.
    Article Snippet: Background: The prognosis of triple-negative breast cancer (TNBC) is notably unfavorable, necessitating the development of novel treatments to enhance therapeutic outcomes.. The underlying mechanisms contributing to the pathogenesis of TNBC remain incompletely understood.. RNA 5′-phosphate and 3’-OH ligase 1 (RLIG1) was found to be the first RNA ligase in humans and may be related to cancer development, but no reports have been reported.



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    SIRT3 is transcriptionally down-regulated by KRAS G12D . A, differential gene expression of nicotinate and nicotinamide metabolism pathways. B, SIRT3 mRNA levels of HPNE cells with KRAS/Off or KRAS/On for 3 h to 96 h. The data are presented as mean ± SD ( n = 3). p values were determined by Student’s t test. ∗∗∗, p < 0.001; ∗∗∗∗, p < 0.0001. C, SIRT3 and KRAS protein levels in HPNE cells with KRAS/Off or KRAS/On for 3 h to 96 h. Cell extracts were analyzed by Western blotting using tubulin as the loading control. Note that the images of KRAS and tubulin bands were derived from the same source images shown in , C and D , as they were from the same experiment. D, effect of <t>SCH772984</t> on expression of ERK1/2, phosphorylated ERK1/2, and SIRT3 protein levels in KRAS/On HPNE cells. Cells were treated with SCH772984 at indicated concentrations for 24 h. Cell extracts were analyzed by Western blotting using vinculin as the loading control. HPNE KRAS/Off cell extracts were used for comparison. E, effect of SCH772984 on expression of ERK1/2, phosphorylated ERK1/2, and SIRT3 protein levels in KRAS/On HEK293 cells. Cells were treated with SCH772984 at indicated concentrations for 24 h. Cell extracts were analyzed by Western blotting using vinculin as the loading control. HEK293 KRAS/Off cell extracts were used for comparison. F, schematic illustration of the promoter activity assay to identify potential KRAS regulated region in the SIRT3 promoter. G, activity of truncated SIRT3 promoters in HPNE KRAS/Off and HPNE KRAS/On (12 h) cells. The data are presented as mean ± SD ( n = 3). p values were determined by Student’s t test. ∗, p < 0.05;∗∗, p < 0.01. HPNE: human pancreatic normal epithelial cell.
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    Image Search Results


    SIRT3 is transcriptionally down-regulated by KRAS G12D . A, differential gene expression of nicotinate and nicotinamide metabolism pathways. B, SIRT3 mRNA levels of HPNE cells with KRAS/Off or KRAS/On for 3 h to 96 h. The data are presented as mean ± SD ( n = 3). p values were determined by Student’s t test. ∗∗∗, p < 0.001; ∗∗∗∗, p < 0.0001. C, SIRT3 and KRAS protein levels in HPNE cells with KRAS/Off or KRAS/On for 3 h to 96 h. Cell extracts were analyzed by Western blotting using tubulin as the loading control. Note that the images of KRAS and tubulin bands were derived from the same source images shown in , C and D , as they were from the same experiment. D, effect of SCH772984 on expression of ERK1/2, phosphorylated ERK1/2, and SIRT3 protein levels in KRAS/On HPNE cells. Cells were treated with SCH772984 at indicated concentrations for 24 h. Cell extracts were analyzed by Western blotting using vinculin as the loading control. HPNE KRAS/Off cell extracts were used for comparison. E, effect of SCH772984 on expression of ERK1/2, phosphorylated ERK1/2, and SIRT3 protein levels in KRAS/On HEK293 cells. Cells were treated with SCH772984 at indicated concentrations for 24 h. Cell extracts were analyzed by Western blotting using vinculin as the loading control. HEK293 KRAS/Off cell extracts were used for comparison. F, schematic illustration of the promoter activity assay to identify potential KRAS regulated region in the SIRT3 promoter. G, activity of truncated SIRT3 promoters in HPNE KRAS/Off and HPNE KRAS/On (12 h) cells. The data are presented as mean ± SD ( n = 3). p values were determined by Student’s t test. ∗, p < 0.05;∗∗, p < 0.01. HPNE: human pancreatic normal epithelial cell.

    Journal: The Journal of Biological Chemistry

    Article Title: KRAS G12D mutation promotes pancreatic tumorigenesis by suppressing sirtuin three via the guanine nucleotide exchange factor RCC1

    doi: 10.1016/j.jbc.2025.111057

    Figure Lengend Snippet: SIRT3 is transcriptionally down-regulated by KRAS G12D . A, differential gene expression of nicotinate and nicotinamide metabolism pathways. B, SIRT3 mRNA levels of HPNE cells with KRAS/Off or KRAS/On for 3 h to 96 h. The data are presented as mean ± SD ( n = 3). p values were determined by Student’s t test. ∗∗∗, p < 0.001; ∗∗∗∗, p < 0.0001. C, SIRT3 and KRAS protein levels in HPNE cells with KRAS/Off or KRAS/On for 3 h to 96 h. Cell extracts were analyzed by Western blotting using tubulin as the loading control. Note that the images of KRAS and tubulin bands were derived from the same source images shown in , C and D , as they were from the same experiment. D, effect of SCH772984 on expression of ERK1/2, phosphorylated ERK1/2, and SIRT3 protein levels in KRAS/On HPNE cells. Cells were treated with SCH772984 at indicated concentrations for 24 h. Cell extracts were analyzed by Western blotting using vinculin as the loading control. HPNE KRAS/Off cell extracts were used for comparison. E, effect of SCH772984 on expression of ERK1/2, phosphorylated ERK1/2, and SIRT3 protein levels in KRAS/On HEK293 cells. Cells were treated with SCH772984 at indicated concentrations for 24 h. Cell extracts were analyzed by Western blotting using vinculin as the loading control. HEK293 KRAS/Off cell extracts were used for comparison. F, schematic illustration of the promoter activity assay to identify potential KRAS regulated region in the SIRT3 promoter. G, activity of truncated SIRT3 promoters in HPNE KRAS/Off and HPNE KRAS/On (12 h) cells. The data are presented as mean ± SD ( n = 3). p values were determined by Student’s t test. ∗, p < 0.05;∗∗, p < 0.01. HPNE: human pancreatic normal epithelial cell.

    Article Snippet: The ERK phosphorylation inhibitor SCH772984 (HY-50846), MYC inhibitor MCYi361 (HY-129600) and AP-1 inhibitor T-5224 (HY-12270) were purchased from MedChemExpress.

    Techniques: Gene Expression, Western Blot, Control, Derivative Assay, Expressing, Comparison, Activity Assay